4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
periplocymarin
CAS: 32476-67-8
Molecular Formula: C30H46O8
4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one - Names and Identifiers
4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one - Physico-chemical Properties
| Molecular Formula | C30H46O8 |
| Molar Mass | 534.68 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Melting Point | 148° |
| Boling Point | 690.9±55.0 °C(Predicted) |
| Specific Rotation(α) | D27 +29° (c = 0.94 in 95% alcohol for the anhydr substance) |
| Solubility | Soluble in chloroform, ethyl acetate, soluble in methanol, DMSO |
| Appearance | White powder |
| pKa | 13.55±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD01740198 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the skin. |
| In vitro study | Periplocymarin inhibits proliferation of PC3, U937, HCT-8, Bel-7402, BGC823, A549, and A2780 cell lines in vitro with IC 50 values of 0.02-0.29 µM. |
4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one - Reference
| Reference Show more | 1. [IF=4.36] Lei Chen et al."Chemical profiling and the potential active constituents responsible for wound healing in Periploca forrestii Schltr."J Ethnopharmacol. 2018 Oct;224:230 2. [IF=3.414] Jinsong Li et al."Effects of Periploca forrestii Schltr on wound healing by Src meditated Mek/Erk and PI3K/Akt signals."J Ethnopharmacol. 2019 Jun;237:116 |
4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one - Reference Information
| biological activity | Periplocymarin is a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound. |
Last Update：2024-04-09 02:00:12
![4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one](http://res.chembk.com/assets/str/2d/3/32/32476-67-8.png)
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View History
4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
67703-68-8
1H-Pyrido[2,3-e][1,2,4]triazepine(9CI)
ethyl 4-(2-furyl)-2-({[(4-methyl-2-quinolinyl)sulfanyl]acetyl}amino)-3-thiophenecarboxylate
(1R,2R)-BOC-ACHC
2α,3β-[[(3aR,4S,6R,7aR)-Tetrahydro-6-methyl-4H-1,3-dioxolo[4,5-c]pyran-3a,4-diyl]bis(oxy)]-11α,14α-dihydroxycarda-4,16,20(22)-trienolide
Cyclohexanol, 2-(dimethyloxidoamino)-1-methyl-4-(1-methylethenyl)-, (1S,2S,4R)-
4-bromoisoindolin-1-one
73928-20-8
67703-68-8
1H-Pyrido[2,3-e][1,2,4]triazepine(9CI)
ethyl 4-(2-furyl)-2-({[(4-methyl-2-quinolinyl)sulfanyl]acetyl}amino)-3-thiophenecarboxylate
(1R,2R)-BOC-ACHC
2α,3β-[[(3aR,4S,6R,7aR)-Tetrahydro-6-methyl-4H-1,3-dioxolo[4,5-c]pyran-3a,4-diyl]bis(oxy)]-11α,14α-dihydroxycarda-4,16,20(22)-trienolide
Cyclohexanol, 2-(dimethyloxidoamino)-1-methyl-4-(1-methylethenyl)-, (1S,2S,4R)-
4-bromoisoindolin-1-one
73928-20-8